Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation
T. Oda, H. Yanagisawa, H. Shinmori, Y. Ogawa, T. Kawamura
This study uses cryo-electron tomography to reveal how langerin trimers interact to form the zippered membrane structure of Birbeck granules, showing that a flexible loop mediates this interaction and is critical for granule formation and HIV internalization.
bioRxiv · Feb 24, 2022Immunology