T. Oda

SLC-25A46 Regulates Mitochondrial Fusion through FZO-1/Mitofusin and is Essential for Maintaining Neuronal Morphology

This study identifies SLC-25A46 as a regulator of mitochondrial fusion through FZO-1/Mitofusin and shows its role in maintaining neuronal morphology.

Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State

This paper uses FRET to study how DPc10 and CaM interact with RyR2, revealing their distinct effects on channel function and structural changes.

Unveiling Liquid-Crystalline Lipids in the Urothelial Membrane through Cryo-EM

This study uses cryo-EM to reveal the structure of the uroplakin complex in porcine urothelial membranes, identifying lipid domains and correcting a previous model.

ROR1 plays a critical role in pancreatic tumor-initiating cells with a partial EMT signature.

This study identifies ROR1 as a critical marker for pancreatic tumor-initiating cells with a partial EMT signature, showing its role in promoting tumor growth and relapse.

Distinct roles of α- and β-tubulin C-terminal tails for ciliary function as revealed by a CRISPR/Cas9 mediated gene editing in Chlamydomonas

The paper uses CRISPR/Cas9 to generate Chlamydomonas mutants with modified tubulin C-terminal tails, revealing distinct roles in ciliary motility and assembly.

Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson's disease-specific hepatocytes

This study uses patient-derived iPSCs to identify retinoids as potential therapeutics for Wilson's disease by rescuing ceruloplasmin secretion and reducing oxidative stress.

Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

This study uses cryo-electron tomography to reveal how langerin trimers interact to form the zippered membrane structure of Birbeck granules, showing that a flexible loop mediates this interaction and is critical for granule formation and HIV internalization.

Puromycin is incorporated into regenerating flagella of Chlamydomonas reinhardtii as an indicator of nascent flagellar proteins

The paper develops a non-radioactive method using puromycin to track nascent flagellar proteins in Chlamydomonas reinhardtii during regeneration.

Cryo-electron tomography of cardiac myofibrils reveals a contraction-induced lattice twist in the Z-discs.

This study uses cryo-electron tomography to reveal contraction-induced lattice twist in Z-discs of cardiac myofibrils, showing structural flexibility in actin-actinin complexes.

Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.

This study determines the 3D structure of murine cardiac thin filaments using cryo-EM with a Volta phase plate, revealing troponin's orientation and interactions with actin and tropomyosin.

Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly

The paper studies zebrafish PIH proteins to determine their roles in axonemal dynein assembly and cilia/flagella motility, finding that each PIH protein is associated with specific dynein subtypes.