T. Kawamura

Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats

This study examines how cardiorespiratory fitness affects epigenetic aging in different organs of rats, finding organ-specific and common changes in DNA methylation.

CD4+ T-cell immunity of SARS-CoV-2 patients determine pneumonia development

This study identifies a specific CD4+ T-cell cluster associated with reduced pneumonia risk in SARS-CoV-2 patients, suggesting immune imbalance contributes to severe disease.

Three-dimensional motions of GroEL during substrate protein recognition

The paper uses cryo-EM to study the 3D motions of GroEL during substrate recognition, revealing asymmetric binding and conformational dynamics at near-atomic resolution.

Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

This study uses cryo-electron tomography to reveal how langerin trimers interact to form the zippered membrane structure of Birbeck granules, showing that a flexible loop mediates this interaction and is critical for granule formation and HIV internalization.

Evaluation of the Efficacy and Safety of a Clinical Grade Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patch: A Pre-Clinical Study

This pre-clinical study evaluates the safety and efficacy of clinical-grade human iPSC-derived cardiomyocyte patches in treating heart failure, showing improved cardiac function and no adverse effects.

HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

This study identifies the HBO1-MLL interaction as critical for leukemogenesis by facilitating the AF4/ENL/P-TEFb complex-mediated gene activation in MLL fusion proteins.

Characterization of the gastric motility response to human motilin and erythromycin in human motilin receptor-expressing transgenic mice

This study shows that human motilin and erythromycin stimulate gastric motility in human motilin receptor-expressing transgenic mice through Ca2+ influx, suggesting these mice are useful for testing MTLR agonists.