H. Yanagisawa

Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases

This paper measures aortic rupture force in mouse models of hereditary aortic diseases to assess biomechanical integrity and drug effects.

Unveiling Liquid-Crystalline Lipids in the Urothelial Membrane through Cryo-EM

This study uses cryo-EM to reveal the structure of the uroplakin complex in porcine urothelial membranes, identifying lipid domains and correcting a previous model.

Distinct roles of α- and β-tubulin C-terminal tails for ciliary function as revealed by a CRISPR/Cas9 mediated gene editing in Chlamydomonas

The paper uses CRISPR/Cas9 to generate Chlamydomonas mutants with modified tubulin C-terminal tails, revealing distinct roles in ciliary motility and assembly.

Parallel cryo electron tomography on in situ lamellae

This paper introduces a method to perform parallel cryo electron tomography on lamella samples, increasing throughput and data collection efficiency.

Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

This study uses cryo-electron tomography to reveal how langerin trimers interact to form the zippered membrane structure of Birbeck granules, showing that a flexible loop mediates this interaction and is critical for granule formation and HIV internalization.

On-site genomic epidemiological analysis of antimicrobial-resistant bacteria in Cambodia with portable laboratory equipment

This study uses portable lab equipment to analyze antimicrobial-resistant bacteria in Cambodia, identifying specific resistance genes and their plasmid locations.

Cryo-electron tomography of cardiac myofibrils reveals a contraction-induced lattice twist in the Z-discs.

This study uses cryo-electron tomography to reveal contraction-induced lattice twist in Z-discs of cardiac myofibrils, showing structural flexibility in actin-actinin complexes.

Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.

This study determines the 3D structure of murine cardiac thin filaments using cryo-EM with a Volta phase plate, revealing troponin's orientation and interactions with actin and tropomyosin.

Inner lumen proteins stabilize doublet microtubules in cilia/flagella

The paper identifies FAP45 and FAP52 as proteins that stabilize microtubules in cilia by binding to their inner structure and preventing detachment.