MMPs and NETs are detrimental in human CNS-tuberculosis and MMP inhibition in a mouse model improves survival
X. Y. Poh, F. K. Loh, C. Bai, H. T. Chong, W. K. Teo, J. M. Hong, Q. H. Miow, P. M. Thong, B. Vilaysane, T. H. Hu, S. Chhabra, Y. Wang, S. C. Tiong, S. M. Fong, M. Kamihigashi, , C. W. M. Ong
The paper identifies elevated MMPs and NETs in CNS-TB patients and shows MMP inhibition improves survival in a mouse model.
bioRxiv · Oct 5, 2023 · PreprintPathology