Tumor-Cell Invasion Initiates at Invasion Hotspots, an Epithelial Tissue-Intrinsic Microenvironment
R. Kobayashi, H. Takishima, S. Deng, Y. Fujita, Y. Tamori
The paper shows that tumor-cell invasion in Drosophila wing imaginal epithelia starts at specific invasion hotspots where JNK signaling and MMP1 activity drive basal extrusion and basement membrane destruction.
bioRxiv · Sep 28, 2021 · PreprintCancer Biology