Y. Fujita

Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.

Mechanical convergence in mixed populations of mammalian epithelial cell

This study measures mechanical properties of mixed mammalian epithelial cell monolayers and finds that cell mechanics converge after mixing.

Restoration of the Functional nif Gene Cluster by Seven Excision and Two Inversion Events during Heterocyst Development in the Nitrogen-Fixing Cyanobacterium Calothrix sp. NIES-4101

The paper identifies a complex recombination process involving seven excision and two inversion events that restores the fragmented nif gene cluster in Calothrix sp. NIES-4101 during heterocyst development.

Multiscale modeling of HBV infection integrating intra- and intercellular viral propagation for analyzing extracellular viral markers

This study develops a multiscale mathematical model to predict intrahepatic cccDNA dynamics using serum viral markers, offering a non-invasive method for HBV infection analysis.

Prediction of elimination of intrahepatic cccDNA in hepatitis B virus-infected patients by a combination of noninvasive viral markers

This study develops a noninvasive method using viral markers to predict cccDNA levels in HBV patients, validated against liver biopsy data.

vRNA-vRNA interactions in influenza A virus HA vRNA packaging

The paper identifies direct RNA-RNA interactions between HA and PB2 vRNAs in influenza A virus that are critical for selective genome packaging and viral replication.

Characterization of various remdesivir-resistant mutations of SARS-CoV-2 by mathematical modeling and molecular dynamics simulation.

This study identifies remdesivir-resistant SARS-CoV-2 mutations using viral reconstruction, mathematical modeling, and molecular dynamics simulations, showing mutations reduce antiviral activity without increasing viral production.

The dgc2 gene encoding di-guanylate cyclase suppresses both motility and biofilm formation in the filamentous cyanobacterium Leptolyngbya boryana.

This study identifies the dgc2 gene in Leptolyngbya boryana, showing that its inactivation suppresses motility and enhances biofilm formation, revealing a novel role for c-di-GMP in colony pattern formation.

Chlamydomonas State Transition Is Quiet Around Pyrenoid and Independent from Thylakoid Deformation

The paper investigates state transition in Chlamydomonas, finding reduced ST activity near the pyrenoid and structural changes independent of LHCII phosphorylation.

Tumor-Cell Invasion Initiates at Invasion Hotspots, an Epithelial Tissue-Intrinsic Microenvironment

The paper shows that tumor-cell invasion in Drosophila wing imaginal epithelia starts at specific invasion hotspots where JNK signaling and MMP1 activity drive basal extrusion and basement membrane destruction.

Phosphate starvation response precedes abscisic acid response under progressive mild drought in plants

The paper shows that phosphate starvation response precedes abscisic acid response in plants under mild drought, using field and controlled experiments.

Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition

Influenza virus ribonucleoprotein complex formation occurs in the nucleolus

This study identifies the nucleolus as the site of vRNP formation and vRNA replication in influenza virus-infected cells.

RNF5 Regulation of RBBP4 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors

This study shows RNF5 promotes AML growth by regulating RBBP4 and epigenetic pathways, and its inhibition enhances sensitivity to HDAC inhibitors, suggesting it as a therapeutic target and biomarker.

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

Src-transformed cells hijack mitosis to extrude from the epithelium

The paper shows that vSrc-transformed cells in zebrafish embryos extrude from epithelia during mitosis by misorienting cytokinetic rings and disrupting apicobasal polarity.