Author

H. Van Oosterwyck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6 Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 6 Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:development & morphogenesis· 3 Organism:human· 3 Research Focus:benchmarking· 2 Approach:deep learning· 2 Assay:imaging· 2

Frequent Co-Authors

A. Shapeti· 4 shared A. Ranga· 3 shared J. A. Sanz-Herrera· 3 shared J. Barrasa-Fano· 3 shared B. Smeets· 2 shared E. Faurobert· 2 shared H. Ramon· 2 shared J. Barrasa Fano· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersBioengineering

A. Shapeti

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth

A. Shapeti, J. Barrasa Fano, A. R. Abdel Fattah, J. de Jong, J. A. Sanz-Herrera, M. Pezet, S. ASSOU, E. de Vet, S. A. Elahi, A. Ranga, E. Faurobert, H. Van Oosterwyck

This study reveals how CCM2-silenced endothelial cells use mechanical forces to recruit and reprogram wild-type cells, driving vascular lesion growth through force-guided invasion and cellular reprogramming.

bioRxiv · Nov 27, 2023Bioengineering

Traction force reconstruction assessment on real three-dimensional matrices and cellular morphologies

A. Apolinar-Fernandez, J. Barrasa-Fano, M. Condor, H. Van Oosterwyck, J. A. Sanz-Herrera

This study assesses the accuracy and efficiency of 3D traction force microscopy (TFM) by evaluating traction reconstruction from synthetic ground truth data under various conditions.

bioRxiv · Nov 16, 2022Cell Biology

Synthetic fibrous hydrogels as a platform to decipher cell-matrix mechanical interactions

H. Yuan, K. Liu, M. Condor, J. Barrasa-Fano, B. Louis, J. Vandaele, P. de Almeida, Q. Coucke, W. Chen, E. Oosterwijk, C. Xing, H. Van Oosterwyck, P. H. J. Kouwer, S. Rocha

This study uses synthetic fibrous hydrogels to investigate cell-matrix mechanical interactions and their impact on cellular behavior.

bioRxiv · Aug 24, 2022 · PreprintBiophysics

TFMLAB: a MATLAB toolbox for 4D traction force microscopy

J. Barrasa Fano, A. Shapeti, A. Jorge-Penas, M. Barzegari, J. A. Sanz Herrera, H. Van Oosterwyck

TFMLAB is a MATLAB toolbox for 4D traction force microscopy that provides an easy-to-use workflow for analyzing in vitro systems.

SoftwareX · Jul 1, 2021Peer-reviewedBioengineering

CCM2 deficient endothelial cells undergo a mechano-dependent reprogramming into senescence associated secretory phenotype used to recruit endothelial and immune cells.

D. R. Vannier, A. Shapeti, F. Chuffart, E. Planus, S. Manet, P. Rivier, o. destaing, C. Albiges-Rizo, H. Van Oosterwyck, E. Faurobert

The paper shows that CCM2-deficient endothelial cells undergo mechano-dependent reprogramming into SASP, recruiting endothelial and immune cells.

bioRxiv · Feb 22, 2021Cell Biology

Advanced in silico validation framework forthree-dimensional Traction Force Microscopy andapplication to an in vitro model of sproutingangiogenesis

J. Barrasa-Fano, A. Shapeti, J. de Jong, A. Ranga, J. A. Sanz-Herrera, H. Van Oosterwyck

This paper develops an in silico framework to validate 3D Traction Force Microscopy methods, showing the inverse method outperforms the forward method in accuracy for traction recovery.

bioRxiv · Dec 8, 2020Bioengineering

Actuation Enhances Patterning in Human Neural Tube Organoids

A. R. A. Fattah, B. Daza, G. Rustandi, M. A. Berrocal-Rubio, B. Gorissen, S. Poovathingal, K. Davie, X. Cao, D. H. Rosenzweig, Y. Lei, R. Finnell, C. Verfaillie, M. Sampaolesi, P. Dedecker, H. Van Oosterwyck, , A. Ranga

The paper shows that applying active mechanical forces to human neural tube organoids enhances their patterning and growth through temporally restricted mechanoregulation.

bioRxiv · Sep 22, 2020Bioengineering

Intercellular adhesion stiffness moderates cell decoupling on stiff substrates

D. A. Vargas, T. Heck, B. Smeets, H. Ramon, H. Parameswaran, H. Van Oosterwyck

This paper develops a computational model of cell pairs on patterned substrates to study how intercellular adhesion stiffness influences cell decoupling on stiff substrates.

bioRxiv · Oct 13, 2019 · PreprintBioengineering

The role of actin protrusion dynamics in cell migration through a degradable viscoelastic extracellular matrix: Insights from a computational model

T. Heck, D. Vargas Arango, B. Smeets, H. Ramon, P. Van Liedekerke, H. Van Oosterwyck

This paper develops a computational model to study how actin protrusion dynamics influence 3D cell migration through a degradable viscoelastic extracellular matrix, revealing key factors affecting migration efficiency and speed.

bioRxiv · Jul 9, 2019Bioengineering