Author

S. Poovathingal

Vlaams Instituut voor Biotechnologie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Animal Behavior & Cognition· 1 Cancer Biology· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:scRNA-seq· 4 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

K. Davie· 3 shared A. R. A. Fattah· 2 shared A. Ranga· 2 shared A. Dashwood· 1 shared A. de Boer· 1 shared A. De Falco· 1 shared A. Golebiewska· 1 shared A. Kerstens· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBioengineering

K. Davie

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single-cell transcriptomics reveals that glial cells integrate homeostatic and circadian processes to drive sleep-wake cycles

J. Dopp, A. Ortega, K. Davie, S. Poovathingal, E.-S. Baz, S. Liu

This study uses single-cell transcriptomics in Drosophila to show glial cells integrate circadian and homeostatic processes to regulate sleep-wake cycles.

bioRxiv · Mar 22, 2023Animal Behavior & Cognition

Extracellular matrix flow guides in-vitro epithelial morphogenesis

A. R. A. Fattah, F. Sgualdino, S. Poovathingal, K. Davie, P. Baatsen, K. Vints, N. Gunko, A. Ranga

The paper shows ECM flow drives epithelial morphogenesis in hPSC monolayers through directional movement and local symmetry breaking, validated by in silico modeling and scRNAseq.

bioRxiv · Oct 21, 2022 · PreprintBioengineering

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

L. Yshii, E. Pasciuto, P. Bielefeld, L. Mascali, P. Lemaitre, M. Marino, J. Dooley, L. Kouser, S. Verschoren, V. Lagou, H. Kemps, P. Gervois, A. de Boer, O. Burton, J. Wahis, , A. Liston

This study delivers IL2 to astrocytes in the brain to increase resident Tregs and protect against neuroinflammation without affecting the peripheral immune system.

bioRxiv · Feb 28, 2022Immunology

Actuation Enhances Patterning in Human Neural Tube Organoids

A. R. A. Fattah, B. Daza, G. Rustandi, M. A. Berrocal-Rubio, B. Gorissen, S. Poovathingal, K. Davie, X. Cao, D. H. Rosenzweig, Y. Lei, R. Finnell, C. Verfaillie, M. Sampaolesi, P. Dedecker, H. Van Oosterwyck, , A. Ranga

The paper shows that applying active mechanical forces to human neural tube organoids enhances their patterning and growth through temporally restricted mechanoregulation.

bioRxiv · Sep 22, 2020Bioengineering

Primary and recurrent glioma patient-derived orthotopic xenografts (PDOX) represent relevant patient avatars for precision medicine

A. Golebiewska, A.-C. Hau, A. Oudin, D. Stieber, Y. A. Yabo, V. Baus, V. Barthelemy, E. Klein, S. Bougnaud, O. Keunen, M. Wantz, A. Michelucci, V. Neirinckx, A. Muller, T. Kaoma, , S. P. Niclou

This study shows that glioma PDOX models accurately represent patient tumors and can predict treatment responses in personalized medicine.

bioRxiv · Apr 24, 2020Cancer Biology

Single nucleus sequencing fails to detect microglial activation

N. Thrupp, Carlo Sala Frigerio, L. Wolfs, Nathan Skene, S. Poovathingal, Y. Fourne, Paul McMahan Matthews, Tom Theys, Renzo Mancuso, Bart De Strooper, Mark W. E. J. Fiers

The paper shows that single nucleus RNA-Seq fails to detect microglial activation genes in human brain samples compared to single cell RNA-Seq.

bioRxiv · Apr 13, 2020 · PreprintNeuroscience