O. Destaing

An optogenetic approach to control and monitor inflammasome activation.

This paper introduces an optogenetic method to control ASC oligomerization, enabling the study of inflammasome activation without PAMPs or DAMPs.

Structural insights into p300 regulation and acetylation-dependent genome organisation

The paper investigates how acetylation reading and writing enable long-range chromosomal interactions through the BRD4-NUT oncogenic fusion protein and p300 activation.

Optogenetic manipulation of YAP cellular localisation and function

This paper develops optoYAP, an optogenetic tool to control YAP localization and function, showing it can regulate gene expression, proliferation, and growth in cell culture and zebrafish embryos.

CCM2 deficient endothelial cells undergo a mechano-dependent reprogramming into senescence associated secretory phenotype used to recruit endothelial and immune cells.

The paper shows that CCM2-deficient endothelial cells undergo mechano-dependent reprogramming into SASP, recruiting endothelial and immune cells.

Molecular flux control encodes distinct cytoskeletal responses by specifying SRC signaling pathway usage.

The paper uses optogenetic control of SRC kinase to show that distinct cytoskeletal responses are encoded by spatial and temporal molecular fluxes of the same signaling protein.