FDA-Approved Drug Screening in Patient-Derived Organoids Demonstrates Potential of Drug Repurposing for Rare Cystic Fibrosis Genotypes
Eyleen de Poel, Sacha Spelier, Marne C. Hagemeijer, Peter van Mourik, Sylvia W.F. Suen, Annelotte M. Vonk, Jesse E. Brunsveld, Georgia N. Ithakisiou, Evelien Kruisselbrink, Hugo Oppelaar, Gitte Berkers, Karin M. de Winter‐de Groot, Sabine Heida-Michel, S.R. Jans, H. van Panhuis, , Jeffrey Matthijn Beekman
The paper screens 1400 FDA-approved drugs in CF patient-derived intestinal organoids using a functional assay to identify potential repurposing for rare CF genotypes.
Journal of Cystic Fibrosis · May 1, 2023Peer-reviewedMolecular Biology