Author

Jesse E. Brunsveld

Utrecht University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jeffrey Matthijn BeekmaniD· 3 shared Eyleen de Poel· 2 shared Amanda Andersson-RolfiD· 1 shared Annelotte M. VonkiD· 1 shared Antoni R. BlaazeriD· 1 shared Carmen ArgmanniD· 1 shared Caroline A. LindemansiD· 1 shared Cayetano Pleguezuelos‐ManzanoiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenetics

Jeffrey Matthijn BeekmanORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Distinct heterozygous TTC7A missense variants lead to different intestinal epithelial phenotypes in pediatric IBD

Zahra Shojaei Jeshvaghani, Polina Deenichina, Lauren V. Collen, Maaike Hillegonda de Vries, Jesse E. Brunsveld, Daniel Kotlarz, Sibylle Koletzko, Christoph Klein, Jeffrey Matthijn Beekman, Scott B. Snapper, Caroline A. Lindemans, Michal Mokrý, Carmen Argmann, Ewart Kuijk, Edward E. S. Nieuwenhuis

This study examines how different TTC7A missense mutations in pediatric IBD patients lead to distinct intestinal epithelial phenotypes.

bioRxiv · Jun 11, 2025 · PreprintGenetics

FDA-Approved Drug Screening in Patient-Derived Organoids Demonstrates Potential of Drug Repurposing for Rare Cystic Fibrosis Genotypes

Eyleen de Poel, Sacha Spelier, Marne C. Hagemeijer, Peter van Mourik, Sylvia W.F. Suen, Annelotte M. Vonk, Jesse E. Brunsveld, Georgia N. Ithakisiou, Evelien Kruisselbrink, Hugo Oppelaar, Gitte Berkers, Karin M. de Winter‐de Groot, Sabine Heida-Michel, S.R. Jans, H. van Panhuis, , Jeffrey Matthijn Beekman

The paper screens 1400 FDA-approved drugs in CF patient-derived intestinal organoids using a functional assay to identify potential repurposing for rare CF genotypes.

Journal of Cystic Fibrosis · May 1, 2023Peer-reviewedMolecular Biology

Evaluating CRISPR-based Prime Editing for cancer modeling and CFTR repair in intestinal organoids

Maarten H. Geurts, Eyleen de Poel, Cayetano Pleguezuelos‐Manzano, Rurika Oka, Léo Carrillo, Amanda Andersson-Rolf, Matteo Boretto, Jesse E. Brunsveld, Ruben van Boxtel, Jeffrey Matthijn Beekman, Hans C. Clevers

This study evaluates prime editing for modeling cancer mutations and repairing CFTR in intestinal organoids, showing its potential but also highlighting challenges in efficiency and off-target effects.

Life Science Alliance · Aug 9, 2021Peer-reviewedGenetics