Nanoparticle-mediated delivery of peptide-based degraders enables targeted protein degradation
S. Ghosal, C. Robertus, J. Wang, H. W. Chan, A. Alamgir, J. Almonte, C. A. Alabi
This study uses lipid nanoparticles to deliver peptide-based degraders, enabling targeted protein degradation in cancer cells and demonstrating reduced target levels in mice.
bioRxiv · Mar 17, 2024 · PreprintBioengineering