Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice
R. R. Goldblum, M. McClellan, C. Hou, B. R. Thompson, K. White, H. X. Vang, H. Cohen, J. M. Metzger, M. K. Gardner
This study shows oxidative stress causes structural changes in cardiac myocyte microtubules, leading to a static, acetylated network that contributes to heart failure.
bioRxiv · Jun 30, 2020Cell Biology