H. Cohen

A T6SS in the coral pathogen Vibrio coralliilyticus secretes an arsenal of anti-eukaryotic effectors and contributes to virulence

This study identifies two temperature-regulated T6SSs in Vibrio coralliilyticus, revealing their roles in bacterial competition and host toxicity, with T6SS2 secreting nine novel anti-eukaryotic toxins.

Distinct ossification trade-offs illuminate the shoulder girdle reconfiguration at the water-to-land transition.

This study identifies Gli3's role in regulating ossification pathways in zebrafish pectoral girdles, revealing developmental trade-offs that may explain the evolution of tetrapod-like structures.

R2R3-MYB EVER links emission of volatiles with epicuticular wax biosynthesis in petunia petal epidermis

This study identifies EVER, a petal-specific MYB activator, linking volatile emission with epicuticular wax biosynthesis in petunia through transcriptomic, genetic, and metabolomic analyses.

A Vibrio T6SS-mediated lethality in a marine animal model

This study shows Vibrio proteolyticus uses T6SS3 to kill Artemia salina, identifying two known and one novel effector contributing to host lethality.

Carotenoid retention during post-harvest storage of Capsicum annuum: the role of the fruit surface structure.

This study identifies that thicker lipid exocarp layers and smooth surfaces in Capsicum annuum enhance carotenoid retention during post-harvest storage by protecting against reactive oxygen species.

Concurrent Contribution of Co-contraction to Error Reduction during Dynamic Adaptation of the Wrist

The paper validates MR-SoftWrist measurements of wrist adaptation and shows that impedance control via co-contraction reduces trajectory errors beyond adaptation.

Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

The paper identifies two novel T6SS effectors from Vibrio that induce pyroptosis via NLRP3 inflammasome activation in mammalian immune cells and reveal a compensatory pathway.

An Effective mRNA-LNP Vaccine Against the Lethal Plague Bacterium

This study develops an mRNA-LNP vaccine against Yersinia pestis, showing it provides full protection against infection in animals.

T cell response following anti COVID-19 BNT162b2 vaccination is maintained against the SARS-CoV-2 Omicron B.1.1.529 variant of concern

The study assesses T cell responses to the ancestral and Omicron SARS-CoV-2 spike proteins post-BNT162b2 vaccination, finding comparable reactivity and a dominant Th1 response.

JADE family proteins regulate proteasome abundance and activity

This study identifies JADE proteins as regulators of proteasome abundance and activity, showing their role in modulating proteasome turnover and stability through direct interactions.

Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular S. Typhimurium

This paper compares the intracellular transcriptomic profiles and phenotypes of Salmonella Paratyphi A and Salmonella Typhimurium during epithelial cell infection, identifying differences in flagella-chemotaxis, SPI-1, and carbon utilization pathways, and showing cytosolic motility and increased invasiveness of SPA.

Nonclinical Safety and Immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs

This study evaluates the safety, immunogenicity, and efficacy of an rVSV-ΔG-SARS-CoV-2-S vaccine in multiple animal species, finding no adverse effects and a robust immune response.

Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice

This study shows oxidative stress causes structural changes in cardiac myocyte microtubules, leading to a static, acetylated network that contributes to heart failure.

Proteomic analysis of necroptotic extracellular vesicles

The paper identifies the protein composition of necroptotic extracellular vesicles and shows their role in modulating immune responses and antigen presentation.

Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome

This study shows that VPRH, a Vibrio leukocidin, induces pyroptotic cell death via NLRP3 inflammasome activation in macrophages, with a second unknown mechanism.