Author

M. K. Gardner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Assay:electronic health records· 2 Approach:biophysical modeling· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

M. McClellan· 3 shared C. Coombes· 2 shared K. White· 2 shared M. Zanic· 2 shared R. R. Goldblum· 2 shared T. A. Reid· 2 shared A. Hoshino· 1 shared A. J. Mauro· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

M. McClellan

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Author profile →

5 papers

Recent·Most cited

Rapid binding to protofilament edge sites facilitates tip tracking of EB1 at growing microtubule plus-ends

S. J. Gonzalez, R. R. Goldblum, K. T. Vu, R. Shoemaker, T. A. Reid, M. McClellan, M. K. Gardner

This study shows that rapid EB1 binding to microtubule protofilament-edge sites enhances its tip-tracking efficiency at growing microtubule plus-ends.

bioRxiv · Jun 7, 2022Cell Biology

Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice

R. R. Goldblum, M. McClellan, C. Hou, B. R. Thompson, K. White, H. X. Vang, H. Cohen, J. M. Metzger, M. K. Gardner

This study shows oxidative stress causes structural changes in cardiac myocyte microtubules, leading to a static, acetylated network that contributes to heart failure.

bioRxiv · Jun 30, 2020Cell Biology

UNC-45A Weakens and Breaks MT Lattice Independent of its Effect on Non-Muscle Myosin II

M. Bazzaro, J. Habicht, A. Mooneyham, A. Hoshino, M. Shetty, X. Zhang, E. Emmings, Q. Yang, C. Coombes, M. K. Gardner

This study shows UNC-45A weakens and breaks microtubule lattices independently of its effect on non-muscle myosin II, with implications for disease treatment.

bioRxiv · Jun 20, 2020Cell Biology

Quantification of Microtubule Stutters: Dynamic Instability Behaviors that are Strongly Associated with Catastrophe

S. M. Mahserejian, J. P. Scripture, A. J. Mauro, E. J. Lawrence, E. M. Jonasson, K. S. Murray, J. Li, M. K. Gardner, M. Alber, M. Zanic, H. V. Goodson

The paper introduces STADIA, a tool to quantify microtubule dynamics, including stutters, and shows stutters precede catastrophes, with CLASP2{gamma} promoting their return to growth.

bioRxiv · Dec 16, 2019Cell Biology

Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends in cells

T. A. Reid, C. Coombes, S. Mukherjee, R. Goldblum, K. White, S. Parmar, M. McClellan, M. Zanic, N. Courtemanche, M. K. Gardner

The paper shows that EB1 tracks microtubule ends by recognizing structural changes, not just GTP-tubulin binding, using simulations and experiments.

bioRxiv · May 13, 2019Cell Biology