Cells With Treg-Specific FOXP3 Demethylation But Low CD25 Are Prevalent In Autoimmunity
R. C. Ferreira, H. Z. Simons, W. Thompson, D. B. Rainbow, X. Yang, A. J. Cutler, J. Oliveira, X. C. Dopico, D. J. Smyth, N. Savinykh, M. Mashar, T. Vyse, D. B. Dunger, H. Baxendale, A. Chandra, , M. L. Pekalski
The paper identifies CD25lowFOXP3+ T cells as a subset of regulatory T cells expanded in autoimmune diseases, characterized by FOXP3 demethylation and distinct functional features.
bioRxiv · May 5, 2017Immunology