W. Thompson

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

The paper identifies 75 fragments that bind to Coxsackievirus A16 2A protease, including 38 unique compounds in the active site, offering a path for broad-spectrum anti-enteroviral inhibitors.

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

This study uses high-throughput crystallographic fragment screening to identify 46 fragment binding poses on ZIKV NS3Hel, providing templates for antiviral drug design.

Similar but distinct: the impact of biomechanical forces and culture age on the production, cargo loading, and biological efficacy of human megakaryocytic extracellular vesicles for applications in cell and gene therapies

This study investigates how biomechanical forces and culture age affect the production and biological activity of megakaryocytic extracellular vesicles (MkEVs), revealing force-dependent differences in miRNA cargo and efficacy.

Kinetic and functional analysis of abundant microRNAs in extracellular vesicles from normal and stressed cultures of Chinese Hamster Ovary (CHO) cells

This study quantifies microRNA and protein levels in CHO cell extracellular vesicles under various stress conditions and assesses their impact on cell viability.

Native and engineered human megakaryocytic extracellular vesicles for targeted non-viral cargo delivery to blood stem cells

This paper demonstrates that native and engineered human megakaryocytic extracellular vesicles can deliver non-viral cargo specifically to hematopoietic stem and progenitor cells, enhancing platelet production in mice.

Mapping the impacts of hurricanes Maria and Irma on banana production area in the Dominican Republic

This study assesses the impact of hurricanes Irma and Maria on banana production in the Dominican Republic using remote sensing data and finds that 11.35% of plantations were damaged, with new plantations often located in high-risk areas.

Cells With Treg-Specific FOXP3 Demethylation But Low CD25 Are Prevalent In Autoimmunity

The paper identifies CD25lowFOXP3+ T cells as a subset of regulatory T cells expanded in autoimmune diseases, characterized by FOXP3 demethylation and distinct functional features.