Macrophage-derived insulin/IGF antagonist ImpL2 regulates systemic metabolism for mounting an effective acute immune response in Drosophila
G. Krejcova, A. Bajgar, P. Nedbalova, J. Kovarova, N. Kamps-Hughes, H. Zemanova, L. Strych, T. Dolezal
This study shows that Drosophila macrophages release ImpL2, an insulin/IGF antagonist, to regulate systemic metabolism during acute immune responses, but this becomes maladaptive in chronic infections.
bioRxiv · Sep 24, 2020 · PreprintImmunology