ImmunologybioRxivPreprint
Macrophage-derived insulin/IGF antagonist ImpL2 regulates systemic metabolism for mounting an effective acute immune response in Drosophila
G. Krejcova, A. Bajgar, P. Nedbalova…·T. Dolezal
This study shows that Drosophila macrophages release ImpL2, an insulin/IGF antagonist, to regulate systemic metabolism during acute immune responses, but this becomes maladaptive in chronic infections.
DOI 10.1101/2020.09.24.311670