Stabilization of AMPK/PFKL/RPIA in the Glycolytic Bodies Transduces IL6/STAT3 Signal in Hepatocarcinogenesis
H.-Y. Hsiao, C.-C. Cheng, Y.-T. Chou, C.-C. Kuo, W.-C. Wang, B. P. Sampurna, Y.-W. Wang, C.-L. Hsiao, J.-Y. Wu, K.-H. Lin, W.-Y. Yang, Y.-H. Lin, K.-H. Gwee, H.-D. Wang, C.-H. Yuh
This study identifies the STAT3/AMPK/PFKL axis in liver cancer, showing how it promotes glycolysis and tumor growth through stabilization of PFKL and RPIA in glycolytic bodies.
bioRxiv · Feb 29, 2024 · PreprintCancer Biology