Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma
H.-H. Lu, S.-Y. Lin, R. R. Weng, Y.-H. Juan, Y.-W. Chen, H.-H. Hou, Z.-C. Hung, G. A. Oswita, Y.-J. Huang, J.-Y. Shih, C.-J. Yu, H.-C. Tsai
This study identifies FUT4 as a key driver of lung adenocarcinoma metastasis through aberrant fucosylation of proteins involved in cell signaling and trafficking, showing its potential as a therapeutic target.
bioRxiv · Nov 11, 2019Cancer Biology