Author

H.-J. Lenz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

A. Schatz· 1 shared A. Y. Yoon· 1 shared B. Haliday· 1 shared C. Cherry· 1 shared C. Shah· 1 shared C. Strelez· 1 shared E. Roussos Torres· 1 shared F. Battaglin· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Schatz

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2 papers

Recent·Most cited

Targeting circadian transcriptional programs in triple negative breast cancer through a cis-regulatory mechanism

Y. Pan, T.-P. Chiu, L. Zhou, P. Chan, T. T. Kuo, F. Battaglin, S. Soni, H.-J. Lenz, P. Jayachandran, J. J. Li, S. Mumenthaler, R. Rohs, E. Roussos Torres, S. A. Kay

This paper identifies a cis-regulatory mechanism in triple-negative breast cancer where targeting circadian transcription factors with small molecules represses a circadian transcriptional program, offering a new therapeutic strategy.

bioRxiv · Apr 26, 2024 · PreprintCancer Biology

Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment

C. Strelez, R. Perez, J. S. Chlystek, C. Cherry, A. Y. Yoon, B. Haliday, C. Shah, K. Ghaffarian, R. X. Sun, H. Jiang, R. Lau, A. Schatz, H.-J. Lenz, J. E. Katz, S. M. Mumenthaler

This paper combines patient-derived organoids with a microfluidic organ-on-chip system to study colorectal cancer invasion under mechanical and GABAergic influences, showing enhanced invasiveness in KRAS mutant tumors.

bioRxiv · Sep 14, 2023 · PreprintCancer Biology