Author

H.-T. Lei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Organism:zebrafish· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1

Frequent Co-Authors

T. Gonen· 4 shared J. Ma· 3 shared S. Sanchez-Martinez· 2 shared C. Nguyen· 1 shared D. Matthies· 1 shared F. E. Reyes· 1 shared L. T. F. Lai· 1 shared M. J. Gallenito· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 20 mutual co-author links

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4 shared papersBiophysics

T. Gonen

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Author profile →

4 papers

Recent·Most cited

Lipid flipping in the omega-3 fatty-acid transporter

T. Gonen, D. Matthies, C. Nguyen, H.-T. Lei, L. T. F. Lai, M. J. Gallenito

This study reports cryo-EM structures of Mfsd2a, revealing the Na+-dependent lipid flipping mechanism for omega-3 fatty acid transport across the BBB and identifying disease-associated mutants.

bioRxiv · May 31, 2022Biophysics

A conformational change in the N terminus of SLC38A9 signals mTORC1 activation

J. Ma, H.-T. Lei, T. Gonen

The paper identifies a conformational change in SLC38A9's N terminus that signals mTORC1 activation in response to amino acid availability.

bioRxiv · Jun 6, 2018Biophysics

Structural basis for substrate binding and specificity of a sodium/alanine symporter AgcS

j. Ma, H.-T. Lei, F. E. Reyes, S. Sanchez-Martinez, M. Sarhan, T. Gonen

This study reports crystal structures of AgcS, an APC transporter, bound to L- and D-alanine, revealing structural features for substrate specificity and stereo-selectivity.

bioRxiv · Apr 3, 2018Biochemistry

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

H.-T. Lei, J. Ma, S. Sanchez-Martinez, T. Gonen

The paper presents the crystal structure of SLC38A9 bound to arginine in the cytosol-open state, revealing the mechanism of amino acid sensing and its role in mTORC1 signaling.

bioRxiv · Mar 24, 2018Biochemistry