D. Matthies

Magnesium Transporter MgtA revealed as a Dimeric P-type ATPase

The paper reports the first structure of the Mg2+ transporter MgtA using cryo-EM, revealing its dimeric form and mechanism of Mg2+ transport.

The lipid-mediated mechanism of mechanosensitive channel MscS inactivation

This study identifies a lipid-mediated mechanism by which the mechanosensitive channel MscS inactivates, showing that intercalated lipids physically decouple tension-sensing helices from the gate.

Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms

This study determines the cryo-EM structures of human MRS2 with and without Mg2+ and identifies key residues and binding sites involved in Mg2+ regulation.

Autolysosomal exocytosis of lipids protect neurons from ferroptosis

The paper shows that autolysosomal exocytosis of lipid-protein particles protects neurons from ferroptosis by removing peroxidated lipids and iron.

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

This paper shows SARS-CoV-2 Orf3a is not an ion channel but interacts with trafficking proteins, while SARS-CoV-1 Orf3a does not.

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

Lipid flipping in the omega-3 fatty-acid transporter

This study reports cryo-EM structures of Mfsd2a, revealing the Na+-dependent lipid flipping mechanism for omega-3 fatty acid transport across the BBB and identifying disease-associated mutants.

The Delta variant SARS-CoV-2 spike protein uniquely promotes aggregation of pseudotyped viral particles

This study shows that Delta variant SARS-CoV-2 spike proteins cause unique viral particle aggregation, which may affect infection kinetics.

Allosteric interactions prime androgen receptor dimerization and activation

This study identifies allosteric interactions that prime androgen receptor dimerization and activation, revealing structural and functional mechanisms relevant to development and disease.

Transport mechanism of the neuronal excitatory amino acid transporter

The paper reports Cryo-EM structures of hEAAT3 in different functional states, revealing an elevator mechanism for glutamate transport and conserved sodium-substrate coupling.