C. Nguyen

Lcn2 protects from cisplatin induced AKI by regulating DNA damage response via EGFR activation

This study shows Lcn2 protects kidneys from cisplatin-induced AKI by activating the EGFR pathway to reduce apoptosis.

Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling

This study shows that circadian rhythm disruption causes abnormal mammary morphology and aggressive basal tumorigenesis by increasing LILRB4 signaling and creating an immunosuppressive tumor microenvironment.

Collecting-Gathering Biophysics of the Blackworm L. variegatus

This study quantitatively examines the collecting-gathering behavior of blackworms, revealing how population size and physical adhesion mechanisms influence particle aggregation and ecological impacts.

Environmental impacts of cultured meat: A cradle-to-gate life cycle assessment

This study conducts a life cycle assessment of near-term cultured meat production, finding its environmental impact could be much higher than median beef production if using refined growth media.

Ancient Fish Lineages Illuminate Toll-Like Receptor Diversification in Early Vertebrate Evolution

This study investigates the diversification of Toll-like receptors (TLRs) across vertebrate evolution using genomic and transcriptomic data, revealing new TLR clades and gene loss patterns linked to adaptive immune system development.

Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

The paper infects diverse mouse strains with a hepacivirus and shows host genetic variation influences viral clearance, chronicity, and liver fibrosis outcomes.

A mathematical model of the disruption of glucose homeostasis in cancer patients

This paper develops a mathematical model to study how cancer disrupts glucose homeostasis and how hyperglycemia affects tumor growth and patient outcomes.

Embracing firefly flash pattern variability with data-driven species classification

This paper develops an automated firefly flash pattern classification system using RNNs to address challenges in species identification and population monitoring.

Response of soil and vegetation in a warm-temperate Pine forest to intensive biomass harvests, phosphorus fertilisation, and wood ash application.

This study evaluates the effects of intensive biomass harvests and nutrient compensation methods on soil and vegetation in a pine forest, finding negative impacts on soil fertility and carbon content despite nutrient additions.

DNA-PAINT single-particle tracking (DNA-PAINT-SPT) enables extended single-molecule studies of membrane protein interactions

This paper introduces dual-colour DNA-PAINT-SPT for live cell imaging, enabling tracking of membrane protein interactions and dimerisation with improved performance over single-dye SPT.

Noisy circumnutations facilitate self-organized shade avoidance in sunflowers

The study highlights noisy circumnutations as a strategy plants use for optimizing growth in crowded conditions.

Lipid flipping in the omega-3 fatty-acid transporter

This study reports cryo-EM structures of Mfsd2a, revealing the Na+-dependent lipid flipping mechanism for omega-3 fatty acid transport across the BBB and identifying disease-associated mutants.

Firefly-inspired vocabulary generator for communication in multi-agent systems

The paper develops a method to simulate firefly flash sequences that minimize similarity, energy cost, and predation risk, producing sequences similar to real fireflies and revealing emergent periodicity.

Single-cell analysis of skeletal muscle macrophages reveals age- associated functional subpopulations

This study identifies age-associated functional subpopulations of skeletal muscle macrophages using single-cell transcriptomics in mice.

Improving Lab Culture Through Self-Assessment: A Case Study

The paper describes a self-assessment process to improve lab culture through surveys and group discussions, resulting in a 12% increase in member satisfaction.

Distinct cell death pathways induced by granzymes collectively protect against intestinal Salmonella infection

This study shows that granzymes A and B use distinct cell death pathways to protect against intestinal Salmonella infection by balancing bacterial growth and translocation.

Gut microbiota analyses of Saudi populations for type 2 diabetes-related phenotypes reveals significant association

The paper analyzes gut microbiota in Saudi populations to identify associations with type 2 diabetes, finding increased Firmicutes abundance and a higher Firmicutes/Bacteroidetes ratio in diabetics.

Emergent collective locomotion in an active polymer model of entangled worm blobs

The paper models worm blobs as active polymers to show how collective locomotion emerges from balancing attractive forces and self-propulsion.

Dopamine and stress signalling interplay patterns social organization in mice

This study shows that dopamine and stress signaling interact to shape social hierarchy in mice, with higher-ranked individuals showing distinct behavioral and neural characteristics.

Variation in pyrethroid resistance phenotypes in Anopheles darlingi from residual malaria transmission area: warning on suspected resistance built-up in French Guiana.

The paper monitors pyrethroid resistance in Anopheles darlingi in French Guiana and suggests metabolic resistance may be responsible for observed resistance without target gene mutations.

Putative Pseudolysogeny-Dependent Phage Gene Implicated in the Superinfection Resistance of Cutibacterium acnes

The paper identifies a phage gene involved in superinfection resistance of C. acnes through pseudolysogeny.

Functional Landscape of SARS-CoV-2 Cellular Restriction

This study identifies key interferon stimulated genes (ISGs) that restrict SARS-CoV-2 infection by inhibiting viral entry, RNA synthesis, and release.

Identification of French Guiana anopheline mosquitoes by MALDI-TOF MS profiling using protein signatures from two body parts.

This study creates and shares reference MALDI-TOF MS spectra for Anopheline species in French Guiana to improve malaria vector identification.

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism

This paper shows that the aneural protist Physarum polycephalum uses mechanosensation to preferentially grow toward heavier, chemically inert masses, revealing a novel biomechanical decision-making mechanism.

Diagnostic Cerebrospinal Fluid Biomarker Discovery and Validation in Patients with Central Nervous System Infections

This study identifies and validates lipocalin 2 (LCN2) as a sensitive and specific biomarker for bacterial meningitis in cerebrospinal fluid.

Tubular STAT3 limits renal inflammation in autosomal dominant polycystic kidney disease

This study shows that STAT3 limits renal inflammation in ADPKD by repressing inflammatory chemokines, despite not driving cyst growth.

Heart rate variability as an indicator of autonomic nervous system disturbance in tetanus

The paper measures heart rate variability in tetanus patients to assess autonomic nervous system dysfunction, finding reduced HRV in those with severe ANSD.

A human ex vivo dengue virus neutralization assay identifies priority antibodies and epitopes for vaccines and therapeutics.

This study develops an ex vivo dengue virus neutralization assay using mosquitoes to identify potent human monoclonal antibodies and their epitopes for vaccine and therapeutic development.

Human cytomegalovirus tropism modulator UL148 interacts with SEL1L, a cellular factor that governs ER-associated degradation of the viral envelope glycoprotein, gO

This study identifies UL148's interaction with SEL1L, showing it stabilizes gO by modulating ERAD, thereby influencing HCMV tropism.