Author

S. Sanchez-Martinez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

D. E. Clapham· 2 shared H.-T. Lei· 2 shared j. Ma· 2 shared K. Nguyen· 2 shared S. Biswas· 2 shared S. E. Brauchi· 2 shared S. KC· 2 shared T. C. Boothby· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiophysics

D. E. Clapham

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Labile assembly of a tardigrade protein induces biostasis

S. Sanchez-Martinez, K. Nguyen, S. Biswas, V. Nicholson, A. V. Romanyuk, J. F. Ramirez, S. KC, A. Akter, C. Childs, E. T. Usher, G. M. Ginell, F. Yu, E. Gollub, M. Malferrari, F. Francia, , T. C. Boothby

This study identifies a mechanism by which tardigrade CAHS D proteins form gels to protect cells during desiccation, showing that gelation reduces molecular motion and metabolic activity, with reversible effects.

bioRxiv · Jun 30, 2023Physiology

Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state

M. H. Packebush, S. Sanchez-Martinez, S. Biswas, S. KC, K. Nguyen, T. C. Boothby

This study shows that natural and engineered desiccation-tolerant mediators can stabilize Human Blood Clotting Factor VIII without cold-chain storage.

bioRxiv · Nov 28, 2022 · PreprintPharmacology & Toxicology

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

A. N. Miller, P. R. Houlihan, E. Matamala, D. Cabezas-Bratesco, G. Y. Lee, B. Cristofori-Armstrong, T. L. Dilan, S. Sanchez-Martinez, D. Matthies, R. Yan, Z. Yu, D. Ren, S. E. Brauchi, D. E. Clapham

This paper shows SARS-CoV-2 Orf3a is not an ion channel but interacts with trafficking proteins, while SARS-CoV-1 Orf3a does not.

bioRxiv · Sep 2, 2022Biophysics

A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility

S.-H. Sheu, S. Upadhyayula, V. Dupuy, S. Pang, A. L. Lemire, D. Walpita, H. A. Pasolli, F. Deng, J. Wan, L. Wang, J. Houser, S. Sanchez-Martinez, S. E. Brauchi, S. Banala, M. Freeman, , D. E. Clapham

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

bioRxiv · Sep 27, 2021Cell Biology

Structural basis for substrate binding and specificity of a sodium/alanine symporter AgcS

j. Ma, H.-T. Lei, F. E. Reyes, S. Sanchez-Martinez, M. Sarhan, T. Gonen

This study reports crystal structures of AgcS, an APC transporter, bound to L- and D-alanine, revealing structural features for substrate specificity and stereo-selectivity.

bioRxiv · Apr 3, 2018Biochemistry

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

H.-T. Lei, J. Ma, S. Sanchez-Martinez, T. Gonen

The paper presents the crystal structure of SLC38A9 bound to arginine in the cytosol-open state, revealing the mechanism of amino acid sensing and its role in mTORC1 signaling.

bioRxiv · Mar 24, 2018Biochemistry