A synthetic biology approach to probing nucleosome symmetry
Yuichi Ichikawa, Caitlin F. Connelly, Alon Chappleboim, Thomas C. R. Miller, Hadas Jacobi, Nebiyu Ali Abshiru, Hsin-Jung Chou, Yuanyuan Chen, Upasna Sharma, Yupeng Zheng, Paul M. Thomas, Hsuiyi V Chen, Vineeta Bajaj, Christoph W. Müller, Neil L. Kelleher, , Paul D. Kaufman
The paper introduces a synthetic biology approach to study nucleosome symmetry by creating asymmetric H3 heterodimers and demonstrates their utility in analyzing histone modification crosstalk.
eLife · Sep 12, 2017Peer-reviewedMolecular Biology