Paul D. Kaufman

The paper introduces OTTR-CLASH, a method that improves the detection of miRNA-target interactions by using a modified RT and enhanced bioinformatics pipeline.

This study identifies a family of lncRNAs, including FRG2A, whose overexpression in FSHD patients disrupts nucleolar architecture and reduces protein synthesis, linking FSHD to muscle wasting.

The paper investigates how D4Z4 repeat length and genotoxic stress affect RNA stability and chromatin association of genes at the 4q35 locus.

The paper maps nucleolus-associated domains (NADs) in mouse embryonic stem cells, revealing developmental differences in their characteristics compared to mouse embryonic fibroblasts.

The paper identifies two distinct classes of Nucleolus-Associated Domains (NADs) in mouse fibroblasts using deep sequencing and a new tool, showing differences in chromatin features and gene expression.

The paper introduces a synthetic biology approach to study nucleosome symmetry by creating asymmetric H3 heterodimers and demonstrates their utility in analyzing histone modification crosstalk.

This study shows that Ki-67 depletion in human cells slows S phase entry and disrupts Xi heterochromatin maintenance, with p21 playing a key role in these effects.