Caitlin F. Connelly

This paper shows that an eIF2B activator rescues neonatal lethality in a VWM mouse model but leads to age-related motor deficits and myelin loss.

This study identifies GDF15 as a biomarker of the Integrated Stress Response in the CNS, showing its correlation with ISR activity in both animal models and human patients.

This study shows that disrupting PGF2α receptor signaling reduces fibrosis in a mouse model of IPF by altering fibroblast dynamics and reducing fibrotic endpoints.

The paper introduces a synthetic biology approach to study nucleosome symmetry by creating asymmetric H3 heterodimers and demonstrates their utility in analyzing histone modification crosstalk.