Intrinsically disordered regions facilitate Msn2 target search to drive promoter selectivity
Nir Strugo, Carmit Burstein, Sk Saddam Hossain, Noam Nago, Moshe Goldsmith, Hadeel Khamis, Ariel Kaplan
This study shows that intrinsically disordered regions in Msn2 enhance DNA binding and promoter selectivity through non-specific association and one-dimensional diffusion.
bioRxiv · May 23, 2025 · PreprintBiophysics