Tunable kinetic destabilization governs RNA polymerase passage through a DNA-bound transcription factor
Noam Nago, Sergei Rudnizky, Nir Strugo, Moshe Goldsmith, Carmit Burstein, Philippa Melamed, Ariel Kaplan
The paper shows DNA-bound Egr-1 delays RNA polymerase elongation through kinetic destabilization, with CpG methylation reducing this delay.
bioRxiv · Jul 30, 2026 · PreprintBiophysics