Heritable changes in chromatin contacts linked to transgenerational obesity
Richard Cheng-An Chang, Riann Jenay Egusquiza, Yikai Huang, Angélica Amorim Amato, Erika M. Joloya, Hailey Brit Wheeler, Angela Nguyen, Keiko Shioda, Junko Odajima, Toshi Shioda, Bruce Blumberg
This study shows that exposure to the obesogen tributyltin causes heritable changes in chromatin structure in germ cells, leading to transgenerational obesity in male offspring.
bioRxiv · Oct 27, 2022 · PreprintDevelopmental Biology