The gut microbiota-derived metabolite indole regulates cytoskeletal functions and virulence in Entamoeba histolytica
Eva Zanditenas, Meirav Trebicz‐Geffen, Yumiko Saito‐Nakano, Seiki Kobayashi, Hajime Hisaeda, Tomoyoshi Nozaki, Yuanning Guo, Smruti Mahapatra, Haguy Wolfenson, Serge Ankri
This study shows that indole, a gut microbiota-derived metabolite, is initially toxic to Entamoeba histolytica but adaptation leads to increased virulence and stress resistance.
bioRxiv · Aug 1, 2025 · PreprintMicrobiology