Prioritization of The Zinc finger domain within BCL11A gene by the Amelioration capability of hemoglobinopathies using CRISPR-Cas9 technology
Kainaat Mumtaz, Irfan Hussain, Fizza Iftikhar, Fawad Ur Rehman, Muhammad Jameel, Safana Farooq, Hammad Hassan, Ambrin Fatima, Oliver Gerhard Ottmann, Afsar Ali Mian
This study uses CRISPR-Cas9 to investigate BCL11A zinc finger domains' role in gamma-globin regulation and hemoglobinopathy treatment, finding Znf4 deletion increases HbF levels.
bioRxiv · Nov 28, 2023 · PreprintMolecular Biology