The novel variant IBDV induces inflammatory responses via VP3-mediated pyroptosis by directly targeting Caspase-9
Tao Zhang, Suyan Wang, Xiaole Qi, Lijie Tang, Yongzhen Liu, Guodong Wang, Hangbo Yu, Yulong Zhang, Ningyu Gao, Ying Wang, Wenrui Fan, Ruihan Zhao, Yuntong Chen, Yanping Zhang, Hongyu Cui, , Yulong Gao
This paper identifies that the novel variant IBDV induces inflammatory responses through VP3-mediated pyroptosis by directly targeting Caspase-9, with Serine 33 as a critical amino acid for this interaction.
bioRxiv · Jan 14, 2026 · PreprintMicrobiology