Tao Zhang

A tumor-cell MHC-II program is associated with checkpoint-blockade outcomes across stages of bladder cancer

This study identifies a tumor-cell MHC-II program linked to immunotherapy outcomes in bladder cancer across different stages and treatment settings.

High-throughput functional characterization of enhancers in totipotent-like cells

The paper functionally characterizes enhancers in totipotent-like cells using reporter assays and integrates with epigenomic and transcriptomic data to show their role in ZGA gene transcription.

Core gastric microbiota linked to pathogenesis and preserved across age stratified cohorts

The paper identifies a core gastric microbiota composed of 11 genera that persists across age groups and is linked to gastric disease risk and cancer.

The novel variant IBDV induces inflammatory responses via VP3-mediated pyroptosis by directly targeting Caspase-9

This paper identifies that the novel variant IBDV induces inflammatory responses through VP3-mediated pyroptosis by directly targeting Caspase-9, with Serine 33 as a critical amino acid for this interaction.

The Red Rice Bran Extract (RRBE) Mitigates Photoaging by Targeting Mitochondrial Oxidative Stress and Regulating Thermal Damage Responses

The paper develops an AI-driven platform to analyze RRBE's photoprotective mechanisms, identifying key bioactive compounds and their targets through computational and experimental validation.

New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin

This study identifies six new genetic variants associated with major adverse cardiovascular events in ACS patients on dual antiplatelet therapy and develops a predictive classifier for MACE.

DNA-mediated self-assembly of gold nanoparticles on protein superhelix

This paper demonstrates a DNA-mediated method to conjugate gold nanoparticles to protein structures, enabling site-specific binding and stable assembly.

Genome-wide analysis of lncRNAs and mRNAs expression during the differentiation of abdominal preadipocytes in chicken

This study identifies lncRNAs and mRNAs expressed during chicken preadipocyte differentiation using RNA-sequencing and finds stage-specific gene modules and pathways involved in the process.

Targeted Deletion of Vitamin D receptor Gene in Mammalian Cells by CRISPR/Cas9 Systems

This study demonstrates that CRISPR/Cas9 can delete large genomic segments in human and mouse cells by using two sgRNAs targeting conserved regions of the VDR gene.