Adaptive potential of a drug-targeted viral protein as a function of environmental stress
Lei Dai, Yushen Du, Hangfei Qi, Christian D. Huber, Nicholas C. Wu, Ergang Wang, James O. Lloyd-Smith, Ren Sun
The paper quantifies the adaptive potential of HCV NS5A protein mutations under drug selection and environmental stress, finding increased beneficial mutations and fitness costs.
bioRxiv · Sep 30, 2016 · PreprintEvolutionary Biology