Author

Lei Dai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Approach:statistical model· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

James O. Lloyd-Smith· 2 shared Nicholas C. WuiD· 2 shared Ren SuniD· 2 shared Arunachalam Ramaiah· 1 shared Baike Liu· 1 shared Bo ZhangiD· 1 shared C. Anders Olson· 1 shared Christian D. Huber· 1 shared

Activity by Year

2016-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersEvolutionary Biology

James O. Lloyd-Smith

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Author profile →

4 papers

Recent·Most cited

Multi-omics reveals AKR1B1-regulated galactose metabolic as a driver of gastrointestinal stromal tumor progression

Xiaonan Yin, Hongxin Yang, Baike Liu, Qinghong Liu, Dan Zhu, Xiaofen Li, Ye Chen, Bo Zhang, Lei Dai, Yuan Yin

This study identifies AKR1B1-regulated galactose metabolism as a driver of gastrointestinal stromal tumor progression through multi-omics analysis.

bioRxiv · May 21, 2024 · PreprintCancer Biology

Adaptive potential of a drug-targeted viral protein as a function of environmental stress

Lei Dai, Yushen Du, Hangfei Qi, Christian D. Huber, Nicholas C. Wu, Ergang Wang, James O. Lloyd-Smith, Ren Sun

The paper quantifies the adaptive potential of HCV NS5A protein mutations under drug selection and environmental stress, finding increased beneficial mutations and fitness costs.

bioRxiv · Sep 30, 2016 · PreprintEvolutionary Biology

Comparative analysis of protein evolution and RNA structural changes in the genome of pre-epidemic and epidemic Zika virus

Arunachalam Ramaiah, Lei Dai, Deisy Contreras, Sanjeev Sinha, Ren Sun, Vaithilingaraja Arumugaswami

This study compares protein evolution and RNA structural changes in pre-epidemic and epidemic Zika virus strains to identify adaptation mechanisms to the human host.

bioRxiv · Apr 26, 2016 · PreprintMicrobiology

Adaptation in protein fitness landscapes is facilitated by indirect paths

Nicholas C. Wu, Lei Dai, C. Anders Olson, James O. Lloyd-Smith, Ren Sun

The paper experimentally characterizes a protein fitness landscape, finding that indirect adaptation paths through extra dimensions can bypass evolutionary traps caused by epistasis.

bioRxiv · Mar 22, 2016Evolutionary Biology