Author

James O. Lloyd-Smith

Primary ORCID profile (0000-0001-7941-502X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

James O. Lloyd-SmithiD1 paper

Biology Disciplines

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Evolutionary Biology· 2 Epidemiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Lei Dai· 2 shared Nicholas C. WuiD· 2 shared Ren SuniD· 2 shared C. Anders Olson· 1 shared Christian D. Huber· 1 shared Claude Loverdo· 1 shared Ergang Wang· 1 shared Hangfei Qi· 1 shared

Activity by Year

2016-2016 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersEvolutionary Biology

Lei Dai

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3 papers

Recent·Most cited

Adaptive potential of a drug-targeted viral protein as a function of environmental stress

Lei Dai, Yushen Du, Hangfei Qi, Christian D. Huber, Nicholas C. Wu, Ergang Wang, James O. Lloyd-Smith, Ren Sun

The paper quantifies the adaptive potential of HCV NS5A protein mutations under drug selection and environmental stress, finding increased beneficial mutations and fitness costs.

bioRxiv · Sep 30, 2016 · PreprintEvolutionary Biology

Cross-scale dynamics and the evolutionary emergence of infectious diseases

Sebastian J. Schreiber, Ruian Ke, Claude Loverdo, Miran Park, Priyanna Ahsan, James O. Lloyd-Smith

The paper develops a stochastic model to analyze how pathogens evolve and emerge in new hosts by linking within-host and between-host dynamics.

bioRxiv · Jul 29, 2016Epidemiology

Adaptation in protein fitness landscapes is facilitated by indirect paths

Nicholas C. Wu, Lei Dai, C. Anders Olson, James O. Lloyd-Smith, Ren Sun

The paper experimentally characterizes a protein fitness landscape, finding that indirect adaptation paths through extra dimensions can bypass evolutionary traps caused by epistasis.

bioRxiv · Mar 22, 2016Evolutionary Biology