CD33KO-CD33-mesothelin loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia
Yao Wang, Xiujuan Zheng, Zhiqian Wang, Ziyun Xiao, Yunqing Lin, Fan Zhang, Yanhong Liu, Pengcheng Liu, Qitong Weng, Leqiang Zhang, Chengxiang Xia, Dehao Huang, Lijuan Liu, Yanping Zhu, Qi Zhang, , Jinyong Wang
This study designs a CD33-mesothelin loop CAR to enhance iNK cell efficacy against AML by avoiding fratricide and improving cytotoxicity.
Journal for ImmunoTherapy of Cancer · Sep 1, 2025Peer-reviewedCancer Biology