Chengxiang Xia

CD33KO-CD33-mesothelin loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia

This study designs a CD33-mesothelin loop CAR to enhance iNK cell efficacy against AML by avoiding fratricide and improving cytotoxicity.

Pluripotent stem cell-derived siTNK cells attack tumors via a synthetic CD8-CD28 TCR complex

The paper generates siTNK cells from hPSCs using a synthetic TCR complex, showing tumor-specific cytotoxicity and anti-tumor activity in xenograft models.

Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignancies

This study generates CD7 CAR-NK cells from pluripotent stem cells that avoid fratricide and effectively suppress T-cell malignancies in xenograft models.

Pluripotent stem cell-derived NK progenitor cell therapy prevents tumour occurrence and eradicates minimal residual disease

This study develops a novel CAR-NK cell therapy using pluripotent stem cell-derived NK progenitors that persist in blood and eliminate minimal residual disease.

Efficient generation of CAR NK cells from human umbilical cord blood CD34+ stem and progenitors for democratizing affordable immunotherapy

This study develops a three-step method to generate high-yield CAR NK cells from umbilical cord blood CD34+ HSPCs, reducing CAR engineering costs and enabling therapeutic applications.