mAbClust with AlphaFold 3 avoids hallucinations to define a quaternary broadly neutralizing HCV epitope
Harry T. Paul, Jessica L. Mimms, Hanna Aboueid, Laura S. Sánchez B., Liudmila Kulakova, Xander E. Wilcox, Katrina Kuhn, H Zhang, Eric A. Toth, Nicole Skinner, Andrew I. Flyak, Gilad Ofek, H. Benjamin Larman, Thomas R. Fuerst, Stuart C. Ray, , Justin R. Bailey
The paper isolates E1-dependent broadly neutralizing antibodies against HCV and uses mAbClust with AlphaFold 3 to map a quaternary epitope spanning E1 and E2.
bioRxiv · Jan 7, 2026 · PreprintImmunology