Xander E. Wilcox

This study classifies three structural classes of HCV broadly neutralizing antibodies targeting the E2 front layer supersite and shows their sensitivity to viral polymorphisms.

The paper isolates E1-dependent broadly neutralizing antibodies against HCV and uses mAbClust with AlphaFold 3 to map a quaternary epitope spanning E1 and E2.

The paper shows that the CRISPR-related enzyme mCpol produces cyclic oligonucleotides to prevent cell death and counteract viral immune evasion.