Shank2 expression identifies a subpopulation of glycinergic interneurons involved in nociception and altered in an autism mouse model
Florian olde Heuvel, Najwa Ouali Alami, Hanna Wilhelm, Dhruva Deshpande, Elmira Khatamsaz, Alberto Catanese, Sarah Woelfle, Michael Schön, Sanjay Jain, Stefanie Grabrucker, Albert Christian Ludolph, Chiara Verpelli, Jens Michaelis, Tobias M. Boeckers, Francesco Roselli
The paper identifies a subpopulation of glycinergic interneurons in the spinal cord regulated by Shank2, whose dysfunction contributes to pain hypersensitivity in ASD mouse models.
bioRxiv · May 24, 2020 · PreprintNeuroscience