Chiara Verpelli

This study shows that inhibiting eEF2K reduces seizures and behavioral issues in a Dravet syndrome mouse model by enhancing GABAergic transmission.

This study shows that deleting calcineurin in astrocytes leads to proteome changes resembling Alzheimer's and epilepsy, and increases seizure risk in mice.

This study shows that restoring glutamate receptosome dynamics in Shank3-deficient mice rescues synaptic and behavioral deficits associated with autism.

This study identifies SULT4A1 as a regulator of synaptic development and function by modulating dendritic morphology and NMDAR synaptic activity through its interaction with Pin1.

The paper identifies a subpopulation of glycinergic interneurons in the spinal cord regulated by Shank2, whose dysfunction contributes to pain hypersensitivity in ASD mouse models.

The paper introduces Beatrix, a tool to amplify weak Cre activity for generating and detecting genetic mosaics in vivo.