Jens Michaelis

The paper introduces hCLARITY, a clearing method that improves the sensitivity and specificity of fluorescence immunostaining in archived human brain tissue for high-resolution imaging.

This study identifies ARF1 as a negative regulator of cGAS-STING signaling, showing it prevents type I IFN induction by regulating STING activation and recycling.

The paper identifies a subpopulation of glycinergic interneurons in the spinal cord regulated by Shank2, whose dysfunction contributes to pain hypersensitivity in ASD mouse models.

This study models the structural changes in the Chd1 protein when bound to nucleosomes, revealing how ATP binding alters its conformation and DNA interactions.