BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.
Hannah Heininger, Xiao Feng, Alp Altunkaya, Fang Zheng, Florian Stockinger, Benedikt Wefers, Stephan A. Müller, Pieter Giesbertz, Sarah K. Tschirner, Dorina Shqau, Helmuth Adelsberger, Alexey A. Ponomarenko, Thomas Fenzl, Christian Alzheimer, Stefan F. Lichtenthaler, Tobias Huth
This study investigates BACE1's role in sleep-wake cycles through enzymatic and non-enzymatic actions using mouse models, finding altered sleep patterns and EEG characteristics in mutants.
EMBO Reports · Nov 20, 2025Peer-reviewedAnimal Behavior & Cognition