Development of compact transcriptional effectors using high-throughput measurements in diverse contexts
Josh Tycko, Mike V. Van, Aradhana, Nicole V. DelRosso, Hanrong Ye, David Yao, Raeline Valbuena, Alun Vaughan-Jackson, Xiaoshu Xu, Connor Ludwig, Kaitlyn K. Spees, Katherine Tin Heng Liu, Mingxin Gu, Venya Khare, Adi Xiyal Mukund, , Michael Cory Bassik
The paper develops HT-recruit to measure transcriptional effector function across contexts and identifies context-dependent effectors for CRISPR-based transcription control.
Nature Biotechnology · Nov 1, 2024Peer-reviewedSystems Biology