Raeline Valbuena

Clonal lineage tracing of innate immune cells in human cancer

The paper uses mtDNA mutations to trace clonal relationships of innate immune cells in cancer, showing myeloid clones are linked to monocytes and have distinct epigenetic profiles.

An image-based CRISPR screen reveals splicing-mediated control of HP1α condensates

The paper uses an image-based CRISPR screen to show splicing regulates HP1α condensates through RNA-chromatin interactions, affecting heterochromatin organization and stress response genes.

Development of compact transcriptional effectors using high-throughput measurements in diverse contexts

The paper develops HT-recruit to measure transcriptional effector function across contexts and identifies context-dependent effectors for CRISPR-based transcription control.

Prediction and design of transcriptional repressor domains with large-scale mutational scans and deep learning

The paper predicts and designs transcriptional repressor domains using mutational scans and a deep learning model called TENet, identifying functional variants and enabling synthetic design.

Klf5 establishes bi-potential cell fate by dual regulation of ICM and TE specification genes

This study identifies Klf5 as a key regulator of bi-potential cell fate in mouse preimplantation embryos by controlling both ICM and TE specification genes.